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To have uncommitted Cd4+Cd8? intermediate thymocytes to tell apart for the CD8+ T tissue, they must terminate Cd4 transcription and reinitiate Cd8 transcription, unit incidents together called �co-receptor reversal’39 (Fig. 4C). Cessation or disruption of TCR signalling inside Cd4+Cd8? it allows IL-7 signalling, and therefore induces Cd4+Cd8? intermediate thymocytes to go through co-receptor reversal to …